Permanent orgasm: possible but not likely

 The closest you'll ever get to a permanent orgasm is mania. In a manic state, the victim is bombarded with pleasure-giving chemicals that simply don't relent. This can lead to a wellbeing never heretofore experienced and even cause the victim to experience God-like powers or to feel that they have discovered the meaning of life, something that has never been revealed to anyone else before. The code has been cracked in their opinion.) Thereafter, the victim sits with a total sense of collapse They feel heavy disappointment and a fractured sense that nothing can or will ever go right again. This feeling of brokenness is only made worse by the memories of exquisite happiness felt in the preceding mania.